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Full Research Papers

2024

Li Z, Kovshova T, Malinovskaya J,Knoll J, Shanehsazzadeh S, Osipova N, Chernysheva A, Melnikov P, Gelperina S, Wacker MG

Blood-Nanoparticle Interactions Create a Brain Delivery Superhighway for Doxorubicin

Int J Nanomedicine. 2024 Mar 5;19:2039-2056. doi: 10.2147/IJN.S440598.

2023

Li Z, Kovshova T, Malinovskaya J, Valikhov M, Melnikov P, Osipova N, Maksimenko O, Dhakal N, Chernysheva A, Chekhonin V, Gelperina S, Wacker MG

Modeling the Drug delivery Lifecycle of PLG Nanoparticles Using Intravital Microscopy

Small. 2023 Dec 28:e2306726. doi: 10.1002/smll.202306726. Online ahead of print.

2023

Wallenwein CM, Ashtikar M, Hofhaus G, Haferland I, Thurn M, König A, Pinter A, Dressman J, Wacker MG.

How wound environments trigger the release from Rifampicin-loaded liposomes

Int J Pharm. 2023 Feb 25;633:122606. doi: 10.1016/j.ijpharm.2023.122606. Epub 2023 Jan 9.

2022

Wallenwein CM, Weigel V, Hofhaus G, Dhakal N, Schatton W, Gelperina S, Groeber-Becker FK, Dressman J, Wacker MG.

Pharmaceutical Development of Nanostructured Vesicular Hydrogel Formulations of Rifampicin for Wound Healing

Int J Mol Sci. 2022 Dec 19;23(24):16207. doi: 10.3390/ijms232416207.

2022

Haferland I, Wallenwein CM, Ickelsheimer T, Diehl S, Wacker MG, Schiffmann S, Buerger C, Kaufmann R, Koenig A, Pinter A.

Mechanism of anti-inflammatory effects of rifampicin in an ex vivo culture system of hidradenitis suppurativa

Exp Dermatol. 2022 Jul;31(7):1005-1013. doi: 10.1111/exd.14531. Epub 2022 Jan 28.

2021

Modh H, Fang DJ, Ou YH, Yau JNN, Kovshova T, Nagpal S, Knoll J, Wallenwein CM, Maiti K, Bhowmick S, Gelperina S, Pastorin G, Wacker MG.

Injectable drug delivery systems of doxorubicin revisited: In vitro-in vivo relationships using human clinical data

Int J Pharm. 2021 Oct 25;608:121073. doi: 10.1016/j.ijpharm.2021.121073. Epub 2021 Sep 2.

2021

Kovshova T, Osipova N, Alekseeva A, Malinovskaya J, Belov A, Budko A, Pavlova G, Maksimenko O, Nagpal S, Braner S, Modh H, Balabanyan V, Wacker MG, Gelperina S.

Exploring the Interplay between Drug Release and Targeting of Lipid-Like Polymer Nanoparticles Loaded with Doxorubicin

Molecules. 2021 Feb 5;26(4):831. doi: 10.3390/molecules26040831.

2021

Jung F, Thurn M, Krollik K, Gao GF, Hering I, Eilebrecht E, Emara Y, Weiler M, Günday-Türeli N, Türeli E, Parnham MJ, Wacker MG.

Predicting the environmental emissions arising from conventional and nanotechnology-related pharmaceutical drug products

Environ Res. 2021 Jan;192:110219. doi: 10.1016/j.envres.2020.110219. Epub 2020 Sep 24.

2020

Nagpal S, Braner S, Modh H, Tan AXX, Mast MP, Chichakly K, Albrecht V, Wacker MG.

A physiologically-based nanocarrier biopharmaceutics model to reverse-engineer the in vivo drug release

Eur J Pharm Biopharm. 2020 Aug;153:257-272. doi: 10.1016/j.ejpb.2020.06.004. Epub 2020 Jun 24.

2019

Wacker MG.

Frontiers in pharmaceutical nanotechnology

Beilstein J Nanotechnol. 2019 Dec 17;10:2538-2540. doi: 10.3762/bjnano.10.244. eCollection 2019.

2019

Jablonka L, Ashtikar M, Gao G, Jung F, Thurn M, Preuß A, Scheglmann D, Albrecht V, Röder B, Wacker MG.

Advanced in silico modeling explains pharmacokinetics and biodistribution of temoporfin nanocrystals in humans

J Control Release. 2019 Aug 28;308:57-70. doi: 10.1016/j.jconrel.2019.06.029. Epub 2019 Jun 24.

2018

Jung F, Nothnagel L, Gao F, Thurn M, Vogel V, Wacker MG.

A comparison of two biorelevant in vitro drug release methods for nanotherapeutics based on advanced physiologically-based pharmacokinetic modelling

Eur J Pharm Biopharm. 2018 Jun;127:462-470. doi: 10.1016/j.ejpb.2018.03.010. Epub 2018 Mar 27.

2016

Janas C, Mostaphaoui Z, Schmiederer L, Bauer J, Wacker MG.

Novel polymeric micelles for drug delivery: Material characterization and formulation screening

Int J Pharm. 2016 Jul 25;509(1-2):197-207. doi: 10.1016/j.ijpharm.2016.05.029. Epub 2016 May 24.

2015

Xie L, Beyer S, Vogel V, Wacker MG, Mäntele W.

Assessing the drug release from nanoparticles: Overcoming the shortcomings of dialysis by using novel optical techniques and a mathematical model

Int J Pharm. 2015 Jul 5;488(1-2):108-19. doi: 10.1016/j.ijpharm.2015.03.080. Epub 2015 Apr 4.

2011

Wacker M, Zensi A, Kufleitner J, Ruff A, Schütz J, Stockburger T, Marstaller T, Vogel V.

A toolbox for the upscaling of ethanolic human serum albumin (HSA) desolvation

Int J Pharm. 2011 Jul 29;414(1-2):225-32. doi: 10.1016/j.ijpharm.2011.04.046. Epub 2011 May 6.

2024

Gan K, Li Z, Darli PM, Wong T, Modh H, Gottier P, Halbherr S, Wacker MG.

Understanding the In Vitro-In Vivo Nexus: Advanced Correlation Models Predict Clinical Performance of Liposomal Doxorubicin

Int J Pharm. 2024 Feb 23:123942. doi: 10.1016/j.ijpharm.2024.123942. Online ahead of print.

2023

Osipova N, Budko A, Maksimenko O, Shipulo E, Vanchugova L, Chen W, Gelperina S, Wacker MG.

Comparison of Compartmental and Non-Compartmental Analysis to Detect Biopharmaceutical Similarity of Intravenous Nanomaterial-Based Rifabutin Formulations

Pharmaceutics. 2023 Apr 17;15(4):1258. doi: 10.3390/pharmaceutics15041258.

2022

Lim XC, Huang C, Yatim SMJM, Chong SY, Tan SH, Yang X, Heldt CL, Pedersen J, Talanker M, Modh H, Wacker MG, Pastorin G, Chan SP, Richards AM, Charles CJ, Chan MY, Wang JW.

Temporal Changes in Extracellular Vesicle Hemostatic Protein Composition Predict Favourable Left Ventricular Remodeling after Acute Myocardial Infarction

Int J Mol Sci. 2022 Dec 25;24(1):327. doi: 10.3390/ijms24010327.

2023

Li Z, Ramirez G, Tang R, Paul CKX, Nair M, Henderson S, Morimoto B, Liu J, Kaasgaard T, Boyd BJ, Wacker MG.

Modeling digestion, absorption, and ketogenesis after administration of tricaprilin formulations to humans

Eur J Pharm Biopharm. 2023 Jan;182:41-52. doi: 10.1016/j.ejpb.2022.11.022. Epub 2022 Dec 5.

2021

Mast MP, Modh H, Knoll J, Fecioru E, Wacker MG.

An Update to Dialysis-Based Drug Release Testing-Data Analysis and Validation Using the Pharma Test Dispersion Releaser

Pharmaceutics. 2021 Nov 25;13(12):2007. doi: 10.3390/pharmaceutics13122007.

2021

Neupane YR, Huang C, Wang X, Chng WH, Venkatesan G, Zharkova O, Wacker MG, Czarny B, Storm G, Wang JW, Pastorin G.

Lyophilization Preserves the Intrinsic Cardioprotective Activity of Bioinspired Cell-Derived Nanovesicles

Pharmaceutics. 2021 Jul 9;13(7):1052. doi: 10.3390/pharmaceutics13071052.

2021

Jung F, Thurn M, Krollik K, Li D, Dressman J, Alig E, Fink L, Schmidt MU, Wacker MG.

Sustained-release hot melt extrudates of the weak acid TMP-001: A case study using PBB modelling

Eur J Pharm Biopharm. 2021 Mar;160:23-34. doi: 10.1016/j.ejpb.2021.01.007. Epub 2021 Jan 20.

2020

Ou YH , Zou S , Goh WJ , Chong SY , Venkatesan G , Wacker MG , Storm G , Wang JW , Czarny B , Pastorin G , Woon ECY .

Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells

Nanoscale. 2020 Sep 21;12(35):18022-18030. doi: 10.1039/d0nr03784b. Epub 2020 Aug 28.

2020

Hering I, Eilebrecht E, Parnham MJ, Günday-Türeli N, Türeli AE, Weiler M, Schäfers C, Fenske M, Wacker MG.

Evaluation of potential environmental toxicity of polymeric nanomaterials and surfactants

Environ Toxicol Pharmacol. 2020 May;76:103353. doi: 10.1016/j.etap.2020.103353. Epub 2020 Feb 7.

2019

Feczkó T, Piiper A, Pleli T, Schmithals C, Denk D, Hehlgans S, Rödel F, Vogl TJ, Wacker MG.

Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques

Pharmaceutics. 2019 Sep 23;11(10):489. doi: 10.3390/pharmaceutics11100489.

2019

Feczkó T, Piiper A, Ansar S, Blixt FW, Ashtikar M, Schiffmann S, Ulshöfer T, Parnham MJ, Harel Y, Israel LL, Lellouche JP, Wacker MG.

Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy

J Control Release. 2019 Jan 10;293:63-72. doi: 10.1016/j.jconrel.2018.11.017. Epub 2018 Nov 17.

2017

Janas C, Mast MP, Kirsamer L, Angioni C, Gao F, Mäntele W, Dressman J, Wacker MG.

The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers

Eur J Pharm Biopharm. 2017 Jun;115:73-83. doi: 10.1016/j.ejpb.2017.02.006. Epub 2017 Feb 16.

2015

Beyer S, Moosmann A, Kahnt AS, Ulshöfer T, Parnham MJ, Ferreirós N, Wagner S, Wacker MG.

Drug Release and Targeting: the Versatility of Polymethacrylate Nanoparticles for Peroral Administration Revealed by Using an Optimized In Vitro-Toolbox

Pharm Res. 2015 Dec;32(12):3986-98. doi: 10.1007/s11095-015-1759-2. Epub 2015 Jul 28.

2014

Wacker MG, Altinok M, Urfels S, Bauer J.

Nanoencapsulation of ultra-small superparamagnetic particles of iron oxide into human serum albumin nanoparticles

Beilstein J Nanotechnol. 2014 Nov 27;5:2259-66. doi: 10.3762/bjnano.5.235. eCollection 2014.

2011

Löw K, Wacker M, Wagner S, Langer K, von Briesen H.

Targeted human serum albumin nanoparticles for specific uptake in EGFR-Expressing colon carcinoma cells

Nanomedicine. 2011 Aug;7(4):454-63. doi: 10.1016/j.nano.2010.12.003. Epub 2011 Jan 5.

2024

Nagpal S, Png JYJ, Malinovskaya J, Kovshova T, Jain P, Naik S, Khopade A, Bhowmick S, Shahi P, Chakra A, Bhokari A, Shah V, Gelperina S, Wacker MG

A Design-Conversed Strategy Establishes the Performance Safe Space for Doxorubicin Nanosimilars

ACS Nano. 2024 Feb 27;18(8):6162-6175. doi: 10.1021/acsnano.3c08290. Epub 2024 Feb 15.

2023

Tong L, Zhang S, Liu Q, Huang C, Hao H, Tan MS, Yu X, Lou CKL, Huang R, Zhang Z, Liu T, Gong P, Ng CH, Muthiah M, Pastorin G, Wacker MG, Chen X, Storm G, Lee CN, Zhang L, Yi H, Wang JW.

Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis

Sci Adv. 2023 Apr 14;9(15):eade5041. doi: 10.1126/sciadv.ade5041. Epub 2023 Apr 12.

2023

Mast MP, Mesquita L, Gan K, Gelperina S, das Neves J, Wacker MG.

Encapsulation and release of hydrocortisone from proliposomes govern vaginal delivery

Drug Deliv Transl Res. 2023 Apr;13(4):1022-1034. doi: 10.1007/s13346-022-01263-x. Epub 2022 Dec 30.

2022

Lee CK, Zhang S, Venkatesan G, Irsan, Chong SY, Wang JW, Goh WJ, Panczyk T, Tay YZ, Hu J, Ng WK, Wacker MG, Toh WS, Pastorin G.

Enhanced skin penetration of berberine from proniosome gel attenuates pain and inflammation in a mouse model of osteoarthritis

Biomater Sci. 2022 Mar 29;10(7):1752-1764. doi: 10.1039/d1bm01733k.

2021

Hajba-Horváth E, Fodor-Kardos A, Shah N, Wacker MG, Feczkó T.

Sustainable Stabilizer-Free Nanoparticle Formulations of Valsartan Using Eudragit(®) RLPO

Int J Mol Sci. 2021 Dec 2;22(23):13069. doi: 10.3390/ijms222313069.

2021

Hering I, Eilebrecht E, Parnham MJ, Weiler M, Günday-Türeli N, Türeli AE, Modh H, Heng PWS, Böhmer W, Schäfers C, Fenske M, Wacker MG.

Microparticle formulations alter the toxicity of fenofibrate to the zebrafish Danio rerio embryo

Aquat Toxicol. 2021 May;234:105798. doi: 10.1016/j.aquatox.2021.105798. Epub 2021 Mar 8.

2021

Gao GF, Ashtikar M, Kojima R, Yoshida T, Kaihara M, Tajiri T, Shanehsazzadeh S, Modh H, Wacker MG.

Predicting drug release and degradation kinetics of long-acting microsphere formulations of tacrolimus for subcutaneous injection

J Control Release. 2021 Jan 10;329:372-384. doi: 10.1016/j.jconrel.2020.11.055. Epub 2020 Nov 30.

2020

Gao GF, Thurn M, Wendt B, Parnham MJ, Wacker MG.

A sensitive in vitro performance assay reveals the in vivo drug release mechanisms of long-acting medroxyprogesterone acetate microparticles

Int J Pharm. 2020 Aug 30;586:119540. doi: 10.1016/j.ijpharm.2020.119540. Epub 2020 Jun 23.

2020

Jablonka L, Ashtikar M, Gao GF, Thurn M, Modh H, Wang JW, Preuß A, Scheglmann D, Albrecht V, Röder B, Wacker MG.

Predicting human pharmacokinetics of liposomal temoporfin using a hybrid in silico model

Eur J Pharm Biopharm. 2020 Apr;149:121-134. doi: 10.1016/j.ejpb.2020.02.001. Epub 2020 Feb 6.

2019

Wallenwein CM, Nova MV, Janas C, Jablonka L, Gao GF, Thurn M, Albrecht V, Wiehe A, Wacker MG.

A dialysis-based in vitro drug release assay to study dynamics of the drug-protein transfer of temoporfin liposomes

Eur J Pharm Biopharm. 2019 Oct;143:44-50. doi: 10.1016/j.ejpb.2019.08.010. Epub 2019 Aug 14.

2019

Nothnagel L, Jung F, Rossmanith T, Thurn M, Ashtikar M, Geisslinger G, Parnham MJ, Wacker MG.

Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001

Eur J Pharm Biopharm. 2019 Jan;134:144-152. doi: 10.1016/j.ejpb.2018.11.012. Epub 2018 Nov 16.

2016

Beyer S, Xie L, Schmidt M, de Bruin N, Ashtikar M, Rüschenbaum S, Lange CM, Vogel V, Mäntele W, Parnham MJ, Wacker MG.

Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques

J Control Release. 2016 Aug 10;235:352-364. doi: 10.1016/j.jconrel.2016.06.013. Epub 2016 Jun 8.

2015

Villa Nova M, Janas C, Schmidt M, Ulshoefer T, Gräfe S, Schiffmann S, de Bruin N, Wiehe A, Albrecht V, Parnham MJ, Luciano Bruschi M, Wacker MG.

Nanocarriers for photodynamic therapy-rational formulation design and medium-scale manufacture

Int J Pharm. 2015 Aug 1;491(1-2):250-60. doi: 10.1016/j.ijpharm.2015.06.024. Epub 2015 Jun 26.

2015

Beyer S, Xie L, Gräfe S, Vogel V, Dietrich K, Wiehe A, Albrecht V, Mäntele W, Wacker MG.

Bridging laboratory and large scale production: preparation and in vitro-evaluation of photosensitizer-loaded nanocarrier devices for targeted drug delivery

Pharm Res. 2015 May;32(5):1714-26. doi: 10.1007/s11095-014-1569-y. Epub 2014 Nov 19.

2010

Wacker M, Chen K, Preuss A, Possemeyer K, Roeder B, Langer K.

Photosensitizer loaded HSA nanoparticles. I: Preparation and photophysical properties

Int J Pharm. 2010 Jun 30;393(1-2):253-62. doi: 10.1016/j.ijpharm.2010.04.022. Epub 2010 Apr 24.

Review Articles

2023

Kamankesh M, Yadegar A, Llopis-Lorente A, Liu C, Haririan I, Aghdaei HA, Shokrgozar MA, Zali MR, Miri AH, Rad-Malekshahi M, Hamblin MR, Wacker MG.

Future Nanotechnology-Based Strategies for Improved Management of Helicobacter pylori Infection

Small. 2023 Sep 11:e2302532. doi: 10.1002/smll.202302532. Online ahead of print.

2022

Lian MQ, Chng WH, Liang J, Yeo HQ, Lee CK, Belaid M, Tollemeto M, Wacker MG, Czarny B, Pastorin G.

Plant-derived extracellular vesicles: Recent advancements and current challenges on their use for biomedical applications

J Extracell Vesicles. 2022 Dec;11(12):e12283. doi: 10.1002/jev2.12283.

2022

Villa Nova M, Lin TP, Shanehsazzadeh S, Jain K, Ng SCY, Wacker R, Chichakly K, Wacker MG.

Nanomedicine Ex Machina: Between Model-Informed Development and Artificial Intelligence

Front Digit Health. 2022 Feb 18;4:799341. doi: 10.3389/fdgth.2022.799341. eCollection 2022.

2021

Huang C, Neupane YR, Lim XC, Shekhani R, Czarny B, Wacker MG, Pastorin G, Wang JW.

Extracellular vesicles in cardiovascular disease

Adv Clin Chem. 2021;103:47-95. doi: 10.1016/bs.acc.2020.08.006. Epub 2020 Oct 1.

2021

Ou YH, Zou S, Goh WJ, Wang JW, Wacker M, Czarny B, Pastorin G.

Cell-Derived Nanovesicles as Exosome-Mimetics for Drug Delivery Purposes: Uses and Recommendations

Methods Mol Biol. 2021;2211:147-170. doi: 10.1007/978-1-0716-0943-9_11.

2018

Ashtikar M, Wacker MG.

Nanopharmaceuticals for wound healing - Lost in translation?

Adv Drug Deliv Rev. 2018 Apr;129:194-218. doi: 10.1016/j.addr.2018.03.005. Epub 2018 Mar 19.

2014

Wacker MG.

Nanotherapeutics--product development along the "nanomaterial" discussion

J Pharm Sci. 2014 Mar;103(3):777-84. doi: 10.1002/jps.23879. Epub 2014 Jan 30.

2023

Pastorin G, Benetti C, Wacker MG.

From in vitro to in vivo: A comprehensive guide to IVIVC development for long-acting therapeutics

Adv Drug Deliv Rev. 2023 Jun 5;199:114906. doi: 10.1016/j.addr.2023.114906. Online ahead of print.

2022

Miri AH, Kamankesh M, Llopis-Lorente A, Liu C, Wacker MG, Haririan I, Asadzadeh Aghdaei H, Hamblin MR, Yadegar A, Rad-Malekshahi M, Zali MR.

The Potential Use of Antibiotics Against Helicobacter pylori Infection: Biopharmaceutical Implications

Front Pharmacol. 2022 Jun 27;13:917184. doi: 10.3389/fphar.2022.917184. eCollection 2022.

2022

Barton AE, Borchard G, Wacker MG, Pastorin G, Saleem IY, Chaudary S, Elbayoumi T, Zhao Z, Flühmann B.

Need for Expansion of Pharmacy Education Globally for the Growing Field of Nanomedicine

Pharmacy (Basel). 2022 Jan 21;10(1):17. doi: 10.3390/pharmacy10010017.

2021

Mast MP, Modh H, Champanhac C, Wang JW, Storm G, Krämer J, Mailänder V, Pastorin G, Wacker MG.

Nanomedicine at the crossroads - A quick guide for IVIVC

Adv Drug Deliv Rev. 2021 Dec;179:113829. doi: 10.1016/j.addr.2021.113829. Epub 2021 Jun 24.

2019

Marques MRC, Choo Q, Ashtikar M, Rocha TC, Bremer-Hoffmann S, Wacker MG.

Nanomedicines - Tiny particles and big challenges

Adv Drug Deliv Rev. 2019 Nov-Dec;151-152:23-43. doi: 10.1016/j.addr.2019.06.003. Epub 2019 Jun 19.

2016

Wacker MG, Proykova A, Santos GML.

Dealing with nanosafety around the globe-Regulation vs. innovation

Int J Pharm. 2016 Jul 25;509(1-2):95-106. doi: 10.1016/j.ijpharm.2016.05.015. Epub 2016 May 13.

2013

Wacker M.

Nanocarriers for intravenous injection--the long hard road to the market

Int J Pharm. 2013 Nov 30;457(1):50-62. doi: 10.1016/j.ijpharm.2013.08.079. Epub 2013 Sep 12.

2023

Alston AB, Digigow R, Flühmann B, Wacker MG.

Putting square pegs in round holes: Why traditional pharmacokinetic principles cannot universally be applied to iron-carbohydrate complexes

Eur J Pharm Biopharm. 2023 Jul;188:6-14. doi: 10.1016/j.ejpb.2023.04.025. Epub 2023 May 2.

2022

Villa Nova M, Gan K, Wacker MG.

Biopredictive tools for the development of injectable drug products

Expert Opin Drug Deliv. 2022 Jun;19(6):671-684. doi: 10.1080/17425247.2022.2081682. Epub 2022 Jun 1.

2023

Li D, Chow PY, Lin TP, Cheow C, Li Z, Wacker MG.

Simulate SubQ: The Methods and the Media

J Pharm Sci. 2023 Jun;112(6):1492-1508. doi: 10.1016/j.xphs.2021.10.031. Epub 2021 Oct 30.

2021

Ou YH, Liang J, Czarny B, Wacker MG, Yu V, Wang JW, Pastorin G.

Extracellular Vesicle (EV) biohybrid systems for cancer therapy: Recent advances and future perspectives

Semin Cancer Biol. 2021 Sep;74:45-61. doi: 10.1016/j.semcancer.2021.02.006. Epub 2021 Feb 17.

2018

Nothnagel L, Wacker MG.

How to measure release from nanosized carriers?

Eur J Pharm Sci. 2018 Jul 30;120:199-211. doi: 10.1016/j.ejps.2018.05.004. Epub 2018 May 8.

2015

Bergs JW, Wacker MG, Hehlgans S, Piiper A, Multhoff G, Rödel C, Rödel F.

The role of recent nanotechnology in enhancing the efficacy of radiation therapy

Biochim Biophys Acta. 2015 Aug;1856(1):130-43. doi: 10.1016/j.bbcan.2015.06.008. Epub 2015 Jul 2.

Other Publications

Workshops, Expert Opinions, Book Chapters

2022

Wacker MG, Lu X, Burke M, Nir I, Fahmy R

Testing the In-Vitro Product Performance of Nanomaterial-Based Drug Products: View of the USP Expert Panel

Diss Tech 2022 Feb 17;29(1): 6-20. doi: 10.14227/DT290122P6

2019

Fecioru E, Klein M, Krämer J, Wacker MG

In vitro performance testing of nanoparticulate drug products for parenteral administration

Diss Tech 2019 Aug 8;26(3) 28-37. doi: 10.14227/DT260319P28

2017

Wacker MG

Nanomedicines – A Scientific Toy or an Emerging Market? in Polymer nanoparticles for Nanomedicines: A Guide for Design, Preparation and Development

Editor(s): Christine Vauthier, Gilles Ponchel, In Polymer Nanoparticles for Nanomedicines: A Guide for their Design, Preparation and Development, Springer, 2017, Pages 623-651, ISBN 3319414208

2022

D’Arcy DM, Wacker MG, Klein S, Shah V, Burke MD, Hunter G, Xu H

In-Vitro Product Performance of Parenteral Drug Products: View of the USP Expert Panel

Diss Tech. 2022 Nov 10;29(4): 204-218. doi: 10.14227/DT290422P204

2018

Wacker MG

LOEWE Workshop Particle Characterization in Medicine and Biology

Pharm Front. 2018 Nov 28, 1:e190002. doi: 10.20900/pf20190002

2017

Wacker MG

Challenges in the drug release testing of next-generation nanomedicines – What do we know?

Mater Today Proc. 2017 Nov 25;4(2):S214-S217. doi: 10.1016/j.matpr.2017.09.189.

2020

Hermans A, Dorozynski P, Muzzio FJ, Li H, Nielsen S, Chen S, Reppas C, Klein S, Patel S, Wacker M, Thakker K, Pruessmann K, Seidlitz A, Ghosh TK, Yang Y, Willett D, Hochhaus G, Tay J, Liew CV, Heng PWS, Sun CC, Kraemer J, Marques MRC

Workshop Report: USP Workshop on Advancements in In Vitro Performance Testing of Drug Products

Diss Tech 2020 May 8; 27(2) 52-70. doi: 10.14227/DT270220P52

2018

Wacker MG, Janas C, Ferreira FS, Vieira FP

Chapter 21 - Manufacturing and Safety Guidelines for Manufactured Functionalized Nanomaterials in Pharmaceutics

Editor(s): Bruno Sarmento, José das Neves, In Micro and Nano Technologies, Biomedical Applications of Functionalized Nanomaterials, Elsevier, 2018, Pages 623-651, ISBN 9780323508780

2015

Wacker M

Suspensionen – Parenteralia, Ophthalmika und perorale Suspensionen: Teilchengrößen-wachstum, Stabilität, Freisetzung

Editor(s): Frank Stieneker, In Partikel in der Pharmaproduktion: Messtechnik – Detektion und Charakterisierung – Regulatorische Anforderungen, ECV, 2016

More Science

Latest Talks, Posters, Abstracts

2024-06

Wacker MG

Computational Biopharmaceutics: Exploring the Drug Delivery Lifecycle of Complex Injectables

DISSO India 2023

Ahmedabad, India

Plenary talk

2023-06

Wacker MG

Biopredictive Tools for Injectables: Long-Acting and Long-Circulating Systems

DISSO 2023

Mumbai, India

Plenary talk

2022-11

Wacker MG

Biopredictive Strategies for Injectables: Tomorrow’s In Vitro-In Silico Toolkit

12th Fresenius Global Preclinical Meeting

Germany

Plenary talk (Virtual)

2022-07

Wacker MG

Nanomedicine Ex Machina: Design Strategies Based on Clinical Relevance

Fraunhofer IAP Seminars

Potsdam, Germany

Invited talk

2022-02

Wacker MG

Evolution of Dissolution Technologies for Novel Dosage Forms

Dissolution Discussion Group webinar

India

Invited talk (Virtual)

2021-09

Wacker MG

Translational Nanomedicine: Biopredictive Tools For Drug Product Development

2nd International Symposium on Drug Delivery Systems

Brazil

Plenary talk (Virtual)

2021-07

Wacker MG

Nanomedicines Revisited: A Facelift For Personalized Therapy?

20th Asian Conference on Clinical Pharmacy

Singapore

Invited talk (Virtual)

2021-04

Modh H

IVIVR for Injectable Nanomedicines – Standing on the Shoulders of Giants

2nd ExplainMyResearch Conference

Singapore

Invited talk (Virtual)

2020-09

Nagpal S, Modh H, Wacker MG

Simulating kinetics of liposomal prednisolone phosphate using physiologically based nano-carrier biopharmaceutics model

AAPS-NUS Student Chapter NUS-Monash Conference

Singapore

Invited talk (Virtual)

2020-06

Wallenwein CM

A dialysis-based in vitro drug release assay to study dynamics of the drug-protein transfer of temoporfin liposomes

SPDS Disso Research Presentations India 2020 Online

India

Invited talk (Virtual)

2020-02

Wacker MG

Translational Nanotechnology – Performance Assays for the Next Generation, CRS Local Chapter India

CRS Local Chapter India

Mumbai, India

Plenary talk

2019-06

Jung F, Thurn M, Krollik K, Gao FG, Hering I, Eilbrecht E, Weiler M, Günday-Türeli N, Türeli E, Parnham MJ, Wacker MG

Simulation of the environmental exposure to fenofibrate nanomaterials based on in vitro- and in silico methods

PAGE Conference

Stockholm, Sweden

Poster abstract

2018-06

Gao F, Villa Nova M, Ashtikar M, Wacker MG

Prediction of human pharmacokinetics of subcutaneously administered depot formulation using MBPK modeling

PAGE conference

Montreux, Switzerland

Post abstract

2018-03

Wacker MG

Challenges in the drug release testing of next-generation nanomedicines

CRS Indian Chapter Meeting

Mumbai, India

Plenary talk

2016-11

Jablonka L, Thurn M, Wacker MG

In vitro drug release testing of liposomal temoporfin formulations with the dispersion releaser technology

GPEN Meeting

Lawrence, USA

Poster abstract

2016

Wacker MG

Challenges in the Drug Release Testing of Next-Generation Nanomedicines

NanoBioMedizin Meeting

Frankfurt, Germany

Plenary talk

2016

Wacker MG

Designing Nanocarriers For Drug Delivery

NRW-Nanokonferenz

Münster, Germany

Plenary talk

2024-06

Wacker MG

Computational Biopharmaceutics: Exploring the Drug Delivery Lifecycle of Complex Injectables

DISSO America 2024

Newark, USA

Plenary talk

2023-05

Wacker MG

Novel Complex Dosage Forms in Drug Delivery: Do We Need A New Biopredictive Toolbox?

PSTS 2023

Singapore

Invited talk

2022-10

Wacker MG

Injectable Nanomedicines: Biopredictive Release Testing and IVIVC

12th Global Summit on Regulatory Science

Singapore

Invited talk

2022-06

Wacker MG

Biopredictive Tools for Injectable Dosage Forms

Global Drug Delivery & Formulation Summit

Berlin, Germany

Plenary talk

2021-11

Wacker MG

Translational Nanomedicine: Crossing Borders in Drug Delivery

Nano Singapore 2021 conference and exhibition

Singapore

Keynote lecture (Virtual)

2021-09

Wacker MG

Novel dosage forms (part II): Parenteral products

3rd SOTAX Congress

Switzerland

Invited talk (Virtual)

2021-04

Wacker MG

Nanomedicines Revisited: A Facelift For Personalized Therapy?

2nd ExplainMyResearch Conference

Singapore

Keynote lecture (Virtual)

2020-11

Wacker MG

Nanomedicine at the crossroads: Why good chemistry is not enough

Beilstein Talks

Germany

Invited talk (Virtual)

2020-09

Wacker MG

Nanomedicine Unleashed – Case Studies on Performance Testing

AAPS-NUS Student Chapter NUS-Monash Virtual Event

Singapore

Keynote lecture (Virtual)

2020-05

Jung F

Nanoparticles and Environmental Protection – A Gordian Knot?; ExplainMyResearch Conference

ExplainMyResearch Conference

Singapore

Invited talk (Virtual)

2019-12

Wacker MG

Dissolution of drug products containing nanomaterials

USP workshop

Rockville, USA

Invited talk

2019-06

Gao FG, Villa Nova M, Ashtikar M, Wacker MG

Prediction of human pharmacokinetics of subcutaneously administered insulin formulations

PAGE conference

Stockholm, Sweden

Poster abstract

2018-06

Jung F, Nothnagel L, Gao F, Wacker MG

Evaluation of release techniques for nanocarriers on the basis of IVIVC-PBPK modeling

PAGE conference

Montreux, Switzerland

Poster abstract

2018-02

Wacker MG

Advances in Nanosized Drug Delivery – Lost in Translation?

LOSAN Drug Delivery Conference

Frankfurt, Germany

Invited talk

2016-11

Nothnagel L, Thurn M, Wacker MG

DoE-based development and in vitro drug release testing of TMP-001 loaded nanocarriers

GPEN Meeting

Lawrence, USA

Poster abstract

2016

Wacker MG

Assessing the drug release from nanocarriers: when, why and how?

PT Indonesia Workshop

Jakarta, Indonesia

Invited talk

2016

Wacker MG

Assessing the drug release from nanocarriers: when, why and how?

LOSAN Drug Delivery Conference

Frankfurt, Germany

Invited talk

2024-05

Wacker MG

Computational Biopharmaceutics: Biopredictive Technologies in the Nanomedicine Design Space

Transporter and Barrier Days

Bad Herrenalb

Oral abstract

2023-02

Wacker MG

Nanotech meets Data Science: Biopredictive Methods in Drug Delivery

PharmNotts Industrial Talk 2023

Malaysia

Invited talk (Virtual)

2022-07

Wacker MG

Nanomedicine Ex Machina: Design Strategies Based on Clinical Relevance

Goethe Graduate Academy for Early Career Researchers Seminars

Frankfurt, Germany

Invited talk

2022-05

Wacker MG

Nanomedicine Ex Machina: Design Strategies Based on Clinical Relevance

13th European and Global Summit for Nanomedicine

Switzerland

Invited talks

2021-11

Wacker MG

Biopredictions in NanoMedicine: Understanding Clinical Data

Annual Meeting of the German Platform NanoBioMedicine

Germany

Plenary talk (Virtual)

2021-09

Wacker MG

Biopredictive Tools for the Development of Injectable Drug Products

11th American Drug Delivery and Formulation Summit

USA

Plenary talk (Virtual)

2021-04

Nagpal S

High-Throughput Nanoformulation Development – A QbD-Based Approach

2nd ExplainMyResearch Conference

Singapore

Invited talk (Virtual)

2020-10

Wacker MG

Nanomedicines today: Quality by Design or Trial and Error?

12th European and Global Summit for Nanomedicine

Switzerland

Invited talk (Virtual)

2020-06

Wacker MG

Nanomedicine in the Spotlight – Unlock your PK

APTI Virtual Seminar

India

Plenary talk (Virtual)

2020-05

Wacker MG

Nanomedicine 2020 – Tiny Giants Unleashed; 1st ExplainMyResearch Conference

1st ExplainMyResearch Conference

Singapore

Invited talk (Virtual)

2019-09

Wacker MG

Translational Nanomedicine – How to predict clinical performance?

Global Summit on Regulatory Science

Stresa, Italy

Plenary talk

2019-03

Wacker MG

Theranostic nanocarriers loaded with nerve growth factor enable enhanced brain recovery after stroke

European Conference on Pharmaceutics

Bologna, Italy

Oral abstract

2018-06

Wacker MG

Nanotechnology in translation – Define, design, produce!

Institute of Materials and Environmental Chemistry/Hungarian Academy of Sciences

Budapest, Hungary

Invited talk

2017-10

Wacker MG

Safety & Regulatory Aspects of Nanomedicines

National University of Singapore Workshop

Singapore

Invited talk

2016-03

Wacker MG

Designing Nanomedicines for the Market

7th Global Drug Delivery and Formulation Summit

Berlin, Germany

Plenary talk

2016

Wacker MG

Assessing the drug release from nanocarriers: when, why and how?

Matrix Analytical Technologies Workshop

Kuala Lumpur, Malaysia

Invited talk

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